137018-55-4
137018-55-4
Chemical Structure
U-83836E
Synonym(s): PNU-83836E
- CAS No.: 137018-55-4
- Formula:C30H46Cl2N6O2
- Molecular Weight:593.63
IUPAC Name: (R)-2-((4-(2,6-di(pyrrolidin-1-yl)pyrimidin-4-yl)piperazin-1-yl)methyl)-2,5,7,8-tetramethylchroman-6-ol dihydrochloride
InChIKey: KJGXSMZHYBXPIS-ZHXNKHNVSA-N
SMILES: OC1=C(C)C(C)=C2C(CC[C@](C)(CN3CCN(C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)CC3)O2)=C1C.Cl.Cl
Biological Activity: U-83836E (PNU-83836E) is a compound with anti-inflammatory and antioxidant activities that reduces lung inflammation inhibiting oxidative stress and ROS production. U-83836E has shown potential for studying asthma and lung inflammation in animal models[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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U-83836E | 98.59% | U-83836E (PNU-83836E) is a compound with anti-inflammatory and antioxidant activities that reduces lung inflammation inhibiting oxidative stress and ROS production. U-83836E has shown potential for studying asthma and lung inflammation in animal models. | ||||||||||||||||||||
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References
- [1]. Camins A, et al. U-83836E prevents kainic acid-induced neuronal damage[J]. Naunyn-Schmiedeberg's archives of pharmacology, 1998, 357: 413-418. [Content Brief]
- [2]. Johnson H G, et al. Late phase bronchoconstriction and eosinophilia as well as methacholine hyperresponsiveness in Ascaris-sensitive rhesus monkeys were reversed by oral administration of U-83836E[J]. International archives of allergy and immunology, 1993, 100(4): 362-366. [Content Brief]
