1392014-36-6
Chemical Structure
Lss-11
- CAS. Nr.: 1392014-36-6
- Formula:C21H27N7O2
- Molecular Weight:409.48
InChIKey: AZOGEZGGVXTPIO-UHFFFAOYSA-N
SMILES: O=C1C2=CC3=C(C4=C2C(C(N1CCN(C)C)=O)=CC(N)=C4)N(CCCN(C)C)N=N3
Biological Activity: Lss-11 is a topoisomerase inhibitor. LSS-11 enhances cell death in cancer cells by inducing apoptosis through increasing the DR5 protein level and PARP1 cleavage. LSS-11 dose-dependently reduces STAT3 phosphorylation, downregulates its target genes MDR1 and MRP1, reduces P-gp protein expressionwithout affecting P-gp transport function. Lss-11 is a chemosensitizer and shows synergistic anticancer effect with Paclitaxel (HY-B0015). Lss-11 can be used for the research of paclitaxel-resistant lung cancer[1].
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Lss-11 | Lss-11 is a topoisomerase inhibitor. LSS-11 enhances cell death in cancer cells by inducing apoptosis through increasing the DR5 protein level and PARP1 cleavage. LSS-11 dose-dependently reduces STAT3 phosphorylation, downregulates its target genes MDR1 and MRP1, reduces P-gp protein expressionwithout affecting P-gp transport function. Lss-11 is a chemosensitizer and shows synergistic anticancer effect with Paclitaxel (HY-B0015). Lss-11 can be used for the research of paclitaxel-resistant lung cancer. | |||||||||||||||||||||
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