1414976-20-7
Chemical Structure
Vazegepant hydrochloride
Synonym(s): Zavegepant hydrochloride; BHV-3500 hydrochloride
- CAS No.: 1414976-20-7
- Formula:C36H47ClN8O3
- Molecular Weight:675.26
IUPAC Name: (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide hydrochloride
InChIKey: VQDUWCSSPSOSNA-RYWNGCACSA-N
SMILES: O=C(N1CCC(C2=CC3=C(NC2=O)C=CC=C3)CC1)N[C@H](CC4=CC5=C(NN=C5)C(C)=C4)C(N6CCN(C7CCN(C)CC7)CC6)=O.[H]Cl
Biological Activity: Vazegepant (Zavegepant hydrochloride; BHV-3500 hydrochloride) hydrochloride is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 23 pM for human CGRP receptor and an EC50 of 880 pM for reversing CGRP-induced vasodilation in human intracranial arteries. Vazegepant hydrochloride can block CGRP-mediated vasodilation in the trigeminal vascular system and inhibit neuronal circuit sensitization. Vazegepant hydrochloride can be used in migraine-related research[1][2].
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Vazegepant hydrochloride | 99.42% | Vazegepant (Zavegepant hydrochloride; BHV-3500 hydrochloride) hydrochloride is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 23 pM for human CGRP receptor and an EC50 of 880 pM for reversing CGRP-induced vasodilation in human intracranial arteries. Vazegepant hydrochloride can block CGRP-mediated vasodilation in the trigeminal vascular system and inhibit neuronal circuit sensitization. Vazegepant hydrochloride can be used in migraine-related research. | ||||||||||||||||||||
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