1. GPCR/G Protein
    Neuronal Signaling
  2. CGRP Receptor
  3. Vazegepant hydrochloride

Vazegepant hydrochloride (Synonyms: Zavegepant hydrochloride; BHV-3500 hydrochloride)

Cat. No.: HY-132131 Purity: 98.01%
Handling Instructions

Vazegepant (BHV-3500) hydrochloride is a highly soluble CGRP receptor antagonist (hCGRP Ki= 0.023 nM). Vazegepant hydrochloride is the first intranasal gepant for migraine. Vazegepant hydrochloride may be helpful in effective management of COVID-19 associated pulmonary inflammation.

For research use only. We do not sell to patients.

Vazegepant hydrochloride Chemical Structure

Vazegepant hydrochloride Chemical Structure

CAS No. : 1414976-20-7

Size Price Stock Quantity
1 mg USD 130 In-stock
Estimated Time of Arrival: December 31
5 mg USD 290 In-stock
Estimated Time of Arrival: December 31
10 mg USD 430 In-stock
Estimated Time of Arrival: December 31
25 mg USD 780 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1180 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Vazegepant (BHV-3500) hydrochloride is a highly soluble CGRP receptor antagonist (hCGRP Ki= 0.023 nM). Vazegepant hydrochloride is the first intranasal gepant for migraine. Vazegepant hydrochloride may be helpful in effective management of COVID-19 associated pulmonary inflammation[1][2][3].

IC50 & Target

Ki: 0.023 nM (hCGRP)[3]

Molecular Weight

675.26

Formula

C₃₆H₄₇ClN₈O₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (74.05 mM; Need ultrasonic)

DMSO : 50 mg/mL (74.05 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4809 mL 7.4046 mL 14.8091 mL
5 mM 0.2962 mL 1.4809 mL 2.9618 mL
10 mM 0.1481 mL 0.7405 mL 1.4809 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.08 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (1.85 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (1.85 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
Vazegepant hydrochloride
Cat. No.:
HY-132131
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