1424565-75-2
Chemical Structure
TF-PPAO
- CAS No.: 1424565-75-2
- Formula:C13H11F3N4O
- Molecular Weight:296.25
SMILES: OC(C1)CN1C2=CC(C(F)(F)F)=NC(C3=CC=CN=C3)=N2
Biological Activity: TF-PPAO is a blood-brain barrier-penetrant mitochondrial calcium uptake inducer (human Kd = 2.82 μM). TF-PPAO binds the MCUB transmembrane pocket and disrupts MCUB-MCU binding, thereby relieving MCUB-mediated restriction, activating pyruvate dehydrogenase activity, and inducing mitochondrial reactive oxygen species (ROS) and oxidative DNA damage. TF-PPAO acts as a radiosensitizer, inhibits tumor growth, and exhibits intracranial tumor accumulation ability, with no detectable systemic toxicity. TF-PPAO can be used for research on glioblastoma[1].
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TF-PPAO | TF-PPAO is a blood-brain barrier-penetrant mitochondrial calcium uptake inducer (human Kd = 2.82 μM). TF-PPAO binds the MCUB transmembrane pocket and disrupts MCUB-MCU binding, thereby relieving MCUB-mediated restriction, activating pyruvate dehydrogenase activity, and inducing mitochondrial reactive oxygen species (ROS) and oxidative DNA damage. TF-PPAO acts as a radiosensitizer, inhibits tumor growth, and exhibits intracranial tumor accumulation ability, with no detectable systemic toxicity. TF-PPAO can be used for research on glioblastoma. | |||||||||||||||||||||
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