145231-45-4
145231-45-4
Chemical Structure
Clobenpropit
- CAS No.: 145231-45-4
- Formula:C14H17ClN4S
- Molecular Weight:308.83
IUPAC Name: 3-(1H-imidazol-5-yl)propyl (4-chlorobenzyl)carbamimidothioate
InChIKey: UCAIEVHKDLMIFL-UHFFFAOYSA-N
SMILES: N=C(SCCCC1=CN=CN1)NCC2=CC=C(Cl)C=C2
Biological Activity: Clobenpropit is a potent histamine H3-receptor antagonist. Clobenpropit decreases dopamine release and increases histamine levels in the hypothalamus. Clobenpropit shows antipsychotic-like activities. Clobenpropit causes a resuscitating effect in rats subjected to the hemorrhagic shock[1][2].
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Clobenpropit | Clobenpropit is a potent histamine H3-receptor antagonist. Clobenpropit decreases dopamine release and increases histamine levels in the hypothalamus. Clobenpropit shows antipsychotic-like activities. Clobenpropit causes a resuscitating effect in rats subjected to the hemorrhagic shock. | |||||||||||||||||||||
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References
- [1]. Mahmood D, et al. The Effect of Subchronic Dosing of Ciproxifan and Clobenpropit on Dopamine and Histamine Levels in Rats. J Exp Neurosci. 2015 Aug 31;9:73-80. [Content Brief]
- [2]. Wanot B, et al. Cardiovascular effects of H3 histamine receptor inverse agonist/ H4 histamine receptor agonist, clobenpropit, in hemorrhage-shocked rats. PLoS One. 2018 Aug 2;13(8):e0201519. [Content Brief]
