145643-96-5
Chemical Structure
Cyclocommunol
- No. CAS: 145643-96-5
- Formula:C20H16O6
- Molecular Weight:352.34
IUPAC Name: 3,8,10-trihydroxy-6-(2-methylprop-1-en-1-yl)-6H,7H-chromeno[4,3-b]chromen-7-one
InChIKey: VHNPAPHWKVLGHG-UHFFFAOYSA-N
SMILES: C/C(C)=C\C1C2=C(OC3=C(C(O)=CC(O)=C3)C2=O)C4=CC=C(O)C=C4O1
Biological Activity: Cyclocommunol is a GST inhibitor with an IC50 of 3.0 μM. Cyclocommunol downregulates the expression of the anti-apoptotic (apoptosis) protein Mcl-1, reduces the levels of phosphorylated Akt and mTOR, and induces caspase-dependent apoptosis, reactive oxygen species (ROS) production and autophagy. Cyclocommunol can be used in research related to oral squamous cell carcinoma, breast cancer, lung cancer, norovirus-induced gastroenteritis and bacterial infections[1][2][3][4][5].
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Cyclocommunol | Cyclocommunol is a GST inhibitor with an IC50 of 3.0 μM. Cyclocommunol downregulates the expression of the anti-apoptotic (apoptosis) protein Mcl-1, reduces the levels of phosphorylated Akt and mTOR, and induces caspase-dependent apoptosis, reactive oxygen species (ROS) production and autophagy. Cyclocommunol can be used in research related to oral squamous cell carcinoma, breast cancer, lung cancer, norovirus-induced gastroenteritis and bacterial infections. | |||||||||||||||||||||
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References
- [1]. Weng JR, et al. Cyclocommunol induces apoptosis in human oral squamous cell carcinoma partially through a Mcl-1-dependent mechanism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jan 15;39:25-32. [Content Brief]
- [2]. Shaha MKK, et al. Flavonoids from the Bark of Artocarpus integer var. silvestris and their Anti-inflammatory Properties. Natural product communications. 2016 Sep;11(9):1275-1278.
- [3]. Chad D, et al. Glutathione S-transferase inhibitory, free radical scavenging, and anti-leishmanial activities of chemical constituents of Artocarpus nobilis and Matricaria chamomilla, Phytochemistry Letters, Volume 3, Issue 4, 2010, Pages 207-211, ISSN 1874-3900,
- [4]. Siddiq Ur Rahman, et al. Innovative phytochemicals based In-Silico drug design and molecular dynamics simulation targeting norovirus induced gastroenteritis, Journal of Molecular Structure, Volume 1332, 2025, 141733, ISSN 0022-2860,
- [5]. Syamsurizal, et al. Semisynthesis and biological activities of derivatives of cyclocommunol from Artocarpus altilis fruit peel. Nat Prod Res. 2026 May;40(9):2402-2409.
