147267-10-5
Chemical Structure
NPC 17731
- CAS No.: 147267-10-5
- Formula:C59H95N19O14
- Molecular Weight:1294.50
IUPAC Name: ((2S,3aS,7aS)-1-((2R,4S)-1-(((2S,4R)-1-(D-arginyl-L-arginyl-L-prolyl)-4-hydroxypyrrolidine-2-carbonyl)glycyl-L-phenylalanyl-L-seryl)-4-propoxypyrrolidine-2-carbonyl)octahydro-1H-indole-2-carbonyl)-L-arginine
InChIKey: NKRDHYAJYOTYPH-HCAPIZDPSA-N
SMILES: O=C([C@@H]1N(C[C@H](C1)OCCC)C([C@H](CO)NC([C@@H](NC(CNC([C@H]2N(C[C@@H](C2)O)C([C@H]3N(CCC3)C([C@H](CCCNC(N)=N)NC([C@H](N)CCCNC(N)=N)=O)=O)=O)=O)=O)CC4=CC=CC=C4)=O)=O)N5[C@]6([H])[C@](CCCC6)([H])C[C@H]5C(N[C@H](C(O)=O)CCCNC(N)=N)=O
Biological Activity: NPC 17731 is a new bradykinin (BK) receptor antagonist. NPC 17731 antagonized both the contractile and relaxant responses caused by BK in longitudinal smooth muscle with IC50 of 23 and 29 nM, respectively[1].
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NPC 17731 | NPC 17731 is a new bradykinin (BK) receptor antagonist. NPC 17731 antagonized both the contractile and relaxant responses caused by BK in longitudinal smooth muscle with IC50 of 23 and 29 nM, respectively. | |||||||||||||||||||||
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Keywords
