147517-06-4
Chemical Structure
Thunberginol C
- CAS No.: 147517-06-4
- Formula:C15H12O5
- Molecular Weight:272.25
IUPAC Name: 6,8-dihydroxy-3-(4-hydroxyphenyl)isochroman-1-one
InChIKey: WMAITHDYVBQITD-UHFFFAOYSA-N
SMILES: O=C1C2=C(O)C=C(O)C=C2CC(C3=CC=C(O)C=C3)O1
Biological Activity: Thunberginol C is an orally active, selective, and non-competitive inhibitor of AChE and BChE, with IC50 values of 41.96 and 42.36 μM, respectively. Thunberginol C exerts cytoprotective, pro-collagen type I restorative, MMP-1 inhibitory, hyaluronic acid restorative, anti-photoaging effects in skin cells. Thunberginol C exerts neuroprotective, anxiolytic, TNF-α inhibitory, neuroinflammation inhibitory, and oxidative stress inhibitory effects. Thunberginol C can be used for the research of Alzheimer’s disease, UVB-induced skin photoaging, allergic reactions, oral bacterial infections, and stress-induced anxiety[1][2][3][4].
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Thunberginol C | Thunberginol C is an orally active, selective, and non-competitive inhibitor of AChE and BChE, with IC50 values of 41.96 and 42.36 μM, respectively. Thunberginol C exerts cytoprotective, pro-collagen type I restorative, MMP-1 inhibitory, hyaluronic acid restorative, anti-photoaging effects in skin cells. Thunberginol C exerts neuroprotective, anxiolytic, TNF-α inhibitory, neuroinflammation inhibitory, and oxidative stress inhibitory effects. Thunberginol C can be used for the research of Alzheimer’s disease, UVB-induced skin photoaging, allergic reactions, oral bacterial infections, and stress-induced anxiety. | |||||||||||||||||||||
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References
- [1]. Hwang J, et al. Discovery of Natural Inhibitors of Cholinesterases from Hydrangea: In Vitro and In Silico Approaches. Nutrients. 2021 Jan 17;13(1):254. [Content Brief]
- [2]. Shin JS, et al. Chemical Constituents from Leaves of Hydrangea serrata and Their Anti-photoaging Effects on UVB-Irradiated Human Fibroblasts. Biol Pharm Bull. 2019;42(3):424-431. [Content Brief]
- [3]. Yoshikawa M, et al. Thunberginols C, D, and E, new antiallergic and antimicrobial dihydroisocoumarins, and thunberginol G 3'-O-glucoside and (-)-hydrangenol 4'-O-glucoside, new dihydroisocoumarin glycosides, from Hydrangeae Dulcis Folium. Chemical & Pharmaceutical Bulletin. 1992 Dec;40(12):3352-3354.
- [4]. Lee J, et al. Hydrangea macrophylla and Thunberginol C Attenuate Stress-Induced Anxiety in Mice. Antioxidants (Basel). 2022 Jan 26;11(2):234. [Content Brief]
