148-72-1
148-72-1
Chemical Structure
Pilocarpine nitrate
- CAS No.: 148-72-1
- Formula:C11H17N3O5
- Molecular Weight:271.27
IUPAC Name: (3S,4R)-3-ethyl-4-((1-methyl-1H-imidazol-5-yl)methyl)dihydrofuran-2(3H)-one nitrate
InChIKey: PRZXEPJJHQYOGF-GNAZCLTHSA-N
SMILES: [O-][N+](O)=O.O=C1OC[C@H](CC2=CN=CN2C)[C@@H]1CC
Biological Activity: Pilocarpine nitrate is an orally active, selective M3 muscarinic acetylcholine receptor agonist. Pilocarpine nitrate can induce seizures and is used in research on conditions such as epilepsy, dry mouth (xerostomia), and elevated intraocular pressure[1][2][3][4].
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Pilocarpine nitrate | 99.87% | Pilocarpine nitrate is an orally active, selective M3 muscarinic acetylcholine receptor agonist. Pilocarpine nitrate can induce seizures and is used in research on conditions such as epilepsy, dry mouth (xerostomia), and elevated intraocular pressure. | ||||||||||||||||||||
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Pilocarpine nitrate (Standard) | ≥98% | Pilocarpine (nitrate) (Standard) is the analytical standard of Pilocarpine (nitrate). This product is intended for research and analytical applications. Pilocarpine nitrate is a potent M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.90
HY-B0726Pilocarpine Hydrochloride -
Similarity Score 0.75
HY-B0726SPilocarpine-d3 hydrochloride -
Similarity Score 0.70
HY-U00038ENS-163 phosphate -
Similarity Score 0.57
HY-W011393L-Anserine nitrate -
Similarity Score 0.54
HY-113354Anserine -
Similarity Score 0.52
HY-108692REnterolactone (Standard) -
Similarity Score 0.52
HY-W778286Enterolactone-13C3 -
Similarity Score 0.51
HY-117745DS-1040 -
Similarity Score 0.51
HY-106993ACipralisant maleate -
Explore the MedChemAI to find more analogs
References
- [1]. Matsuzaki K, et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93. [Content Brief]
- [2]. Yuan XL, et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9(4):505-11. [Content Brief]
- [3]. Tonta MA, et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112(2):525-32. [Content Brief]
- [4]. Manuela Mazzuferi, et al. Rapid epileptogenesis in the mouse pilocarpine model: Video-EEG, pharmacokinetic and histopathological characterization. Experimental Neurology.
