1497415-41-4
Chemical Structure
SB24011
- CAS No.: 1497415-41-4
- Formula:C34H38N4O7
- Molecular Weight:614.69
InChIKey: UZVHJOMTRTYDKL-BHDXBOSCSA-N
SMILES: O=C(NC[C@H]1OCCC1)C2=CC=C(N3[C@H](C(C)C)C(N(CC4=CC=C(O)C=C4)C(CC5=CC=C(OC)C=C5)=C3)=O)C([N+]([O-])=O)=C2
Biological Activity: SB24011 is a STING modulator and a TRIM29-STING protein-protein interaction inhibitor. SB24011 blocks TRIM29-induced K48-linked specific ubiquitination by binding to STING, thereby upregulating intracellular STING protein levels. SB24011 enhances inflammatory cytokine expression and STING-mediated immune responses, and exhibits abscopal antitumor activity that promotes tumor regression and activates T cell infiltration. When combined with STING agonists or anti-PD1 antibodies, SB24011 synergistically enhances antitumor responses. SB24011 is suitable for research related to colon cancer and melanoma[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SB24011 | 99.7% | SB24011 is a STING modulator and a TRIM29-STING protein-protein interaction inhibitor. SB24011 blocks TRIM29-induced K48-linked specific ubiquitination by binding to STING, thereby upregulating intracellular STING protein levels. SB24011 enhances inflammatory cytokine expression and STING-mediated immune responses, and exhibits abscopal antitumor activity that promotes tumor regression and activates T cell infiltration. When combined with STING agonists or anti-PD1 antibodies, SB24011 synergistically enhances antitumor responses. SB24011 is suitable for research related to colon cancer and melanoma. | ||||||||||||||||||||
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- [1]. Park S B, et al. Inhibition of protein-protein interaction between STING and TRIM29 is a new approach to enhance anti-tumor immune response[J]. Cancer Research, 2022, 82(12_Supplement): 667-667.
- [2]. Cho W, et al. Targeted Protein Upregulation of STING for Boosting the Efficacy of Immunotherapy. Angew Chem Int Ed Engl. 2023;62(18):e202300978. [Content Brief]
- [3]. Cho W, et al. STING upregulation strategies to potentiate STING immunotherapy[J]. Future Medicinal Chemistry, 2023, 15(20): 1819-1822.
Keywords
