150450-53-6
150450-53-6
Chemical Structure
MBCQ
- CAS No.: 150450-53-6
- Formula:C16H12ClN3O2
- Molecular Weight:313.74
IUPAC Name: N-(benzo[d][1,3]dioxol-5-ylmethyl)-6-chloroquinazolin-4-amine
InChIKey: CNODHOSDWZLJGA-UHFFFAOYSA-N
SMILES: ClC1=CC2=C(N=CN=C2NCC3=CC4=C(C=C3)OCO4)C=C1
Biological Activity: MBCQ is a potent and selective cGMP-specific phosphodiesterase (PDE V; PDE5) inhibitor with an IC50 of 19 nM. MBCQ lacks inhibitory activity toward other PDE isozymes (all IC50s>100 μM). MBCQ dilates coronary arteries via specific inhibition of cGMP-PDE[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MBCQ | 99.80% | MBCQ is a potent and selective cGMP-specific phosphodiesterase (PDE V; PDE5) inhibitor with an IC50 of 19 nM. MBCQ lacks inhibitory activity toward other PDE isozymes (all IC50s>100 μM). MBCQ dilates coronary arteries via specific inhibition of cGMP-PDE. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.66
HY-101826ER21355 -
Similarity Score 0.65
HY-160896Autophagy-IN-5 -
Similarity Score 0.65
HY-101826AER21355 hydrochloride -
Similarity Score 0.61
HY-12990Spautin-1 -
Similarity Score 0.59
HY-117608ML 315 -
Similarity Score 0.58
HY-117608AML 315 hydrochloride -
Similarity Score 0.58
HY-113848AEM1 -
Similarity Score 0.57
HY-19987RBML-284 (Standard) -
Similarity Score 0.56
HY-19987ABML-284 hydrochloride -
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References
- [1]. Y Takase, et al. Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37(13):2106-11. [Content Brief]
- [2]. Jeffery D MacPherson, et al. Inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation J Pharmacol Exp Ther. 2006 Apr;317(1):188-95. [Content Brief]
- [3]. Takeharu Kaneda, et al. Lack of cyclic nucleotide regulation of MBCQ-induced relaxation of rat ileal smooth muscle. J Smooth Muscle Res. 2003 Jun;39(3):47-54. [Content Brief]
