15489-90-4
Chemical Structure
Hematin
- No. CAS: 15489-90-4
- Formula:C34H33FeN4O5
- Molecular Weight:633.49
IUPAC Name: iron(III) 2,18-bis(2-carboxyethyl)-3,7,12,17-tetramethyl-8,13-divinylporphyrin-21,23-diide hydroxide
InChIKey: BMUDPLZKKRQECS-HXFTUNQESA-K
SMILES: CC1=C(CCC(O)=O)C([N-]C1=CC(C(C)=C2C=C)=NC2=CC3=C4C)=CC(C(CCC(O)=O)=C5C)=NC5=CC([N-]3)=C4C=C.[Fe+3].[OH-]
Biological Activity: Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins[1]. Hematin can be used for the research of acute porphyrias and cancer[1][2][3][4][5].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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Hematin | 95.08% | Hematin, an iron-containing porphyrin, inhibits the activity of clotting factors and also fibrin clot lysis through the mechanism of binding to and inactivation of hemostatic proteins. Hematin can be used for the research of acute porphyrias and cancer. | ||||||||||||||||||||
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- [1]. Siegert SW, et al. Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review. Adv Ther. 2008 Sep;25(9):842-57. [Content Brief]
- [2]. Green D, et al. The inactivation of hemostatic factors by hematin. J Lab Clin Med. 1983;102: 361-369. [Content Brief]
- [3]. Amin ML, et al. Development of hematin conjugated PLGA nanoparticle for selective cancer targeting. Eur J Pharm Sci. 2016 Aug 25;91:138-43. [Content Brief]
- [4]. Goetsch C, et al. Instability of hematin used in the treatment of acute hepatic porphyria. N Engl J Med. 1986;315: 235-238. [Content Brief]
- [5]. Quadros HC, et al. The Role of the Iron Protoporphyrins Heme and Hematin in the Antimalarial Activity of Endoperoxide Drugs. Pharmaceuticals (Basel). 2022;15(1):60. Published 2022 Jan 4. [Content Brief]
Keywords
