155206-00-1
Chemical Structure
Bimatoprost
Synonym(s): AGN 192024
- CAS No.: 155206-00-1
- Formula:C25H37NO4
- Molecular Weight:415.57
IUPAC Name: (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-5-phenylpent-1-en-1-yl)cyclopentyl)-N-ethylhept-5-enamide
InChIKey: AQOKCDNYWBIDND-FTOWTWDKSA-N
SMILES: O=C(NCC)CCC/C=C\C[C@@H]1[C@@H](/C=C/[C@@H](O)CCC2=CC=CC=C2)[C@H](O)C[C@@H]1O
Biological Activity: Bimatoprost is a prostaglandin analog that reduces intraocular pressure by regulating scleral and trabecular outflow. Bimatoprost is used in the study of open-angle glaucoma, ocular hypertension, and other forms of glaucoma. Topical application of bimatoprost induces fat atrophy and causes a deepening of the eyelid sulcus[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Bimatoprost | 99.98% | Bimatoprost is a prostaglandin analog that reduces intraocular pressure by regulating scleral and trabecular outflow. Bimatoprost is used in the study of open-angle glaucoma, ocular hypertension, and other forms of glaucoma. Topical application of bimatoprost induces fat atrophy and causes a deepening of the eyelid sulcus. | ||||||||||||||||||||
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Bimatoprost (Standard) | ≥98% | Bimatoprost (Standard) is the analytical standard of Bimatoprost. This product is intended for research and analytical applications. Bimatoprost is a prostaglandin analog that reduces intraocular pressure by regulating scleral and trabecular outflow. Bimatoprost is used in the study of open-angle glaucoma, ocular hypertension, and other forms of glaucoma. Topical application of bimatoprost induces fat atrophy and causes a deepening of the eyelid sulcus. | ||||||||||||||||||||
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Bimatoprost-d5 | 98.24% | Bimatoprost-d5 is a deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog and is a topical hypotensive agent frequently used for treating ocular hypertension and glaucoma. Bimatoprost also has an antiadipogenic effect. | ||||||||||||||||||||
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Bimatoprost-d4 | 98.10% | Bimatoprost-d4 is the deuterium labeled Bimatoprost. Bimatoprost is a prostaglandin analog used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. The product specifications provided below refer solely to the active content of Bimatoprost-d4. |
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Similarity Score 1.00
HY-114867(15R)-Bimatoprost -
Similarity Score 1.00
HY-B0191A5,6-trans-Bimatoprost -
Similarity Score 0.92
HY-12019717-Phenyl trinor prostaglandin F2α methyl amide -
Similarity Score 0.90
HY-17990117-Phenyl trinor prostaglandin F2α isopropyl amide -
Similarity Score 0.88
HY-B0191CN-Desethyl Bimatoprost -
Similarity Score 0.88
HY-124243N-Cyclopropyl methyl bimatoprost -
Similarity Score 0.88
HY-14955417-Phenyl trinor Prostaglandin F2α dimethyl amide -
Similarity Score 0.88
HY-125774Bimatoprost acid -
Similarity Score 0.88
HY-13912115(R)-17-Phenyl trinor Prostaglandin F2α -
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References
- [1]. Park J, et al. Changes to upper eyelid orbital fat from use of topical bimatoprost, travoprost, and latanoprost. Jpn J Ophthalmol. 2011 Jan;55(1):22-7. [Content Brief]
- [2]. Filippopoulos T, et al. Periorbital changes associated with topical bimatoprost. Ophthal Plast Reconstr Surg. 2008 Jul-Aug;24(4):302-7. [Content Brief]
- [3]. Stamer W D, et al. Proposed mechanism of long-term intraocular pressure lowering with the bimatoprost implant[J]. Investigative Ophthalmology & Visual Science, 2023, 64(3): 15-15. [Content Brief]
- [4]. Patil A J, et al. Bimatoprost–a review[J]. Expert opinion on pharmacotherapy, 2009, 10(16): 2759-2768. [Content Brief]
- [5]. Woodward, et al. "Bimatoprost: a novel antiglaucoma agent." Cardiovascular drug reviews 22.2 (2004): 103-120. [Content Brief]
- [6]. Crowston, et al. "Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice." Investigative ophthalmology & visual science 46.12 (2005): 4571-4577. [Content Brief]
