1629160-83-3
Chemical Structure
MSU38225
- CAS No.: 1629160-83-3
- Formula:C21H19N3
- Molecular Weight:313.40
InChIKey: JHTIZTJUILGBKV-UHFFFAOYSA-N
SMILES: N#CC1=C(NC2=CC(C)=CC(C)=C2)N=C(C)C(C3=CC=CC=C3)=C1
Biological Activity: MSU38225 is a selective Nrf2 inhibitor. MSU38225 increases ROS levels by inhibiting antioxidant production. MSU38225 arrests cells at the G2/M phase, enhances cellular sensitivity to chemotherapeutic agents, and exerts synergistic effects with Carboplatin (HY-17393) and 5-fluorouracil (HY-90006). MSU38225 exhibits anticancer activity against lung cancer. MSU38225 can be used in research related to non-small cell lung cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MSU38225 | 99.94% | MSU38225 is a selective Nrf2 inhibitor. MSU38225 increases ROS levels by inhibiting antioxidant production. MSU38225 arrests cells at the G2/M phase, enhances cellular sensitivity to chemotherapeutic agents, and exerts synergistic effects with Carboplatin (HY-17393) and 5-fluorouracil (HY-90006). MSU38225 exhibits anticancer activity against lung cancer. MSU38225 can be used in research related to non-small cell lung cancer. | ||||||||||||||||||||
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- [1]. Zhang D, et al. A Novel Nrf2 Pathway Inhibitor Sensitizes Keap1-Mutant Lung Cancer Cells to Chemotherapy. Molecular cancer therapeutics. 2021 Sep;20(9):1692-1701. [Content Brief]
- [2]. Hou Z, et al. Exploring structural effects in a new class of NRF2 inhibitors. RSC Med Chem. 2022 Nov 16;14(1):74-84. [Content Brief]
Keywords
