1629160-83-3
Chemical Structure
MSU38225
- CAS No.: 1629160-83-3
- Formula:C21H19N3
- Molecular Weight:313.40
InChIKey: JHTIZTJUILGBKV-UHFFFAOYSA-N
SMILES: N#CC1=C(NC2=CC(C)=CC(C)=C2)N=C(C)C(C3=CC=CC=C3)=C1
Biological Activity: MSU38225 is a selective Nrf2 inhibitor. MSU38225 increases ROS levels by inhibiting antioxidant production. MSU38225 arrests cells at the G2/M phase, enhances cellular sensitivity to chemotherapeutic agents, and exerts synergistic effects with Carboplatin (HY-17393) and 5-fluorouracil (HY-90006). MSU38225 exhibits anticancer activity against lung cancer. MSU38225 can be used in research related to non-small cell lung cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
MSU38225 | 99.94% | MSU38225 is a selective Nrf2 inhibitor. MSU38225 increases ROS levels by inhibiting antioxidant production. MSU38225 arrests cells at the G2/M phase, enhances cellular sensitivity to chemotherapeutic agents, and exerts synergistic effects with Carboplatin (HY-17393) and 5-fluorouracil (HY-90006). MSU38225 exhibits anticancer activity against lung cancer. MSU38225 can be used in research related to non-small cell lung cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.58
HY-156915Pim-1 kinase inhibitor 13 -
Similarity Score 0.58
HY-187161IL-4-IN-3 -
Similarity Score 0.57
HY-159707MCL1020 -
Similarity Score 0.56
HY-105418WIN-63291 -
Similarity Score 0.55
HY-W4564441,4-Bis(2,6-dimethylpyridin-4-yl)benzene -
Similarity Score 0.55
HY-101957RAG 1295 (Standard) -
Similarity Score 0.55
HY-W674276WAY-325485 -
Similarity Score 0.54
![5,5',5''-Trimethyl-[1,1':3',1''-terphenyl]-2,2',2''-triol Chemical Structure](//file.medchemexpress.com/product_pic/hy-w124417.gif)
HY-W1244175,5',5''-Trimethyl-[1,1':3',1''-terphenyl]-2,2',2''-triol -
Similarity Score 0.54
HY-144116A1AR antagonist 2 -
Explore the MedChemAI to find more analogs
![5,5',5''-Trimethyl-[1,1':3',1''-terphenyl]-2,2',2''-triol Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w124417.gif)
References
- [1]. Zhang D, et al. A Novel Nrf2 Pathway Inhibitor Sensitizes Keap1-Mutant Lung Cancer Cells to Chemotherapy. Molecular cancer therapeutics. 2021 Sep;20(9):1692-1701. [Content Brief]
- [2]. Hou Z, et al. Exploring structural effects in a new class of NRF2 inhibitors. RSC Med Chem. 2022 Nov 16;14(1):74-84. [Content Brief]
