1630760-60-9
1630760-60-9
Chemical Structure
(R)-DNMDP
- CAS No.: 1630760-60-9
- Formula:C15H20N4O3
- Molecular Weight:304.34
IUPAC Name: (R)-6-(4-(diethylamino)-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one
InChIKey: YOSSKNZHADPXJX-SNVBAGLBSA-N
SMILES: O=C1C[C@@H](C)C(C2=CC=C(N(CC)CC)C([N+]([O-])=O)=C2)=NN1
Biological Activity: (R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. (R)-DNMDP has a 500-fold lower EC50 compared to the (S)-enantiomer in HeLa cell line[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(R)-DNMDP | 99.59% | (R)-DNMDP is a potent and selective cancer cell cytotoxic agent. (R)-DNMDP, the R-form of DNMDP, binds PDE3A directly. (R)-DNMDP has a 500-fold lower EC50 compared to the (S)-enantiomer in HeLa cell line. | ||||||||||||||||||||
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References
- [1]. de Waal L, et al. Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics. Nat Chem Biol. 2016 Feb;12(2):102-8. Nat Chem Biol. 2016 Feb;12(2):102-8. [Content Brief]
- [2]. Luc DE WAAL, et al. Compositions and methods for cancer expressing pde3a or slfn12. WO2017027854A1.
Keywords
