1660107-77-6
1660107-77-6
Chemical Structure
MAP855
- CAS No.: 1660107-77-6
- Formula:C28H23ClF2N6O3
- Molecular Weight:564.97
IUPAC Name: 1-((3S,4S)-4-(8-(2-chloro-4-(pyrimidin-2-yloxy)phenyl)-7-fluoro-2-methyl-1H-imidazo[4,5-c]quinolin-1-yl)-3-fluoropiperidin-1-yl)-2-hydroxyethan-1-one
InChIKey: WZZBNLYBHUDSHF-DHLKQENFSA-N
SMILES: CC1=NC2=C(C3=CC(C4=C(C=C(C=C4)OC5=NC=CC=N5)Cl)=C(F)C=C3N=C2)N1[C@]6([H])[C@H](CN(CC6)C(CO)=O)F
Biological Activity: MAP855 is a highly potent, selective, ATP-competitive and orally active MEK1/2 kinase inhibitor (MEK1 ERK2 cascade IC50=3 nM, pERK EC50=5 nM). MAP855 shows equipotent inhibition of wild-type and mutant MEK1/2[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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MAP855 | 98.37% | MAP855 is a highly potent, selective, ATP-competitive and orally active MEK1/2 kinase inhibitor (MEK1 ERK2 cascade IC50=3 nM, pERK EC50=5 nM). MAP855 shows equipotent inhibition of wild-type and mutant MEK1/2. | ||||||||||||||||||||
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