16985-03-8
16985-03-8
Chemical Structure
Nonabine
Synonym(s): BRL-4664
- CAS No.: 16985-03-8
- Formula:C25H33NO2
- Molecular Weight:379.54
IUPAC Name: 2,2-dimethyl-7-(3-methyloctan-2-yl)-4-(pyridin-4-yl)-2H-chromen-5-ol
InChIKey: YHUDSHIRWOVVCV-UHFFFAOYSA-N
SMILES: OC1=C2C(C3=CC=NC=C3)=CC(C)(OC2=CC(C(C(CCCCC)C)C)=C1)C
Biological Activity: Nonabine (BRL-4664) is an orally active chromenol derivative and Cannabinoid-like antiemetic. Nonabine controls nausea and vomiting induced by cancer chemotherapy regimens. Nonabine can be used in the research of lymphoma and chemotherapy-induced nausea and vomiting[1][2].
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Nonabine | 99.95% | Nonabine (BRL-4664) is an orally active chromenol derivative and Cannabinoid-like antiemetic. Nonabine controls nausea and vomiting induced by cancer chemotherapy regimens. Nonabine can be used in the research of lymphoma and chemotherapy-induced nausea and vomiting. | ||||||||||||||||||||
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References
- [1]. Archer CB, et al. Antiemetic effect of nonabine in cancer chemotherapy: a double blind study comparing nonabine and chlorpromazine. Br Med J (Clin Res Ed). 1983 Jan 29;286(6362):350-1. [Content Brief]
- [2]. Gardner D V, et al. A versatile approach to analogues of the cannabinoid‐like anti‐emetic nonabine (BRL 4664)[J]. Journal of heterocyclic chemistry, 1984, 21(1): 121-127.
