170381-16-5
170381-16-5
Chemical Structure
Zicronapine
Synonym(s): Lu 31-130
- CAS No.: 170381-16-5
- Formula:C22H27ClN2
- Molecular Weight:354.92
IUPAC Name: 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine
InChIKey: BYPMJBXPNZMNQD-PZJWPPBQSA-N
SMILES: CC1(C)N(C)CCN([C@@H]2C[C@@H](C3=CC=CC=C3)C4=C2C=C(Cl)C=C4)C1
Biological Activity: Zicronapine is an antipsychotic agent with a strong pro-cognitive effect in animal models and the potential to treat a number of neurological and psychiatric diseases. Zicronapine has potent antagonistic effects at dopamine D1/D2, and serotonin 5-HT2A receptors[1][2].
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Zicronapine | Zicronapine is an antipsychotic agent with a strong pro-cognitive effect in animal models and the potential to treat a number of neurological and psychiatric diseases. Zicronapine has potent antagonistic effects at dopamine D1/D2, and serotonin 5-HT2A receptors. | |||||||||||||||||||||
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References
- [1]. Lopez De Diego, Heidi. et al. Succinate and malonate salts of trans-4-(1R,3S)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and their preparation, pharmaceutical compositions, and use as medicaments, particularly as antipsychotics. WO2005016900A1
- [2]. Lundbeck H. A/S. The clinical phase III programme commenced on zicronapine. 20 Jan 2011.
Keywords
