171009-07-7
Chemical Structure
CCT018159
- CAS No.: 171009-07-7
- Formula:C20H20N2O4
- Molecular Weight:352.38
IUPAC Name: 4-(4-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylbenzene-1,3-diol
InChIKey: OWPMENVYXDJDOW-UHFFFAOYSA-N
SMILES: CC1=C(C2=CC3=C(OCCO3)C=C2)C(C4=CC(CC)=C(O)C=C4O)=NN1
Biological Activity: CCT018159 is an ATP-competitive HSP90β inhibitor, with an IC50 of 3.2 μM against human HSP90β ATPase and 6.6 μM against yeast HSP90β ATPase. CCT018159 induces cell cycle arrest and apoptosis in tumor cells, and inhibits invasion and angiogenesis. CCT018159 is applicable to cancer-related research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CCT018159 | 99.30% | CCT018159 is an ATP-competitive HSP90β inhibitor, with an IC50 of 3.2 μM against human HSP90β ATPase and 6.6 μM against yeast HSP90β ATPase. CCT018159 induces cell cycle arrest and apoptosis in tumor cells, and inhibits invasion and angiogenesis. CCT018159 is applicable to cancer-related research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Sharp SY, et al. In vitro biological characterization of a novel, synthetic diaryl pyrazole resorcinol class of heat shock protein 90 inhibitors. Cancer Res. 2007;67(5):2206-2216. [Content Brief]
- [2]. Sbiera S, et al. Hsp90 inhibition in adrenocortical carcinoma: Limited drug synergism with mitotane. Mol Cell Endocrinol. 2019;480:36-41. [Content Brief]
Keywords
