172889-49-5
Chemical Structure
CSP1
- CAS No.: 172889-49-5
- Formula:C103H168N30O24S
- Molecular Weight:2242.69
SMILES: NCCCC[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC([C@H](CCCCN)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CCSC)NC([C@@H](N)CCC(O)=O)=O)=O)=O)=O)=O)=O)CC1=CC=CC=C1)=O)CC2=CC=CC=C2)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O)=O
Biological Activity: CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CSP1 | 98.07% | CSP1 is a potent and selective ComD1 receptor agonist, with an IC50 of 10.3 nM. CSP1 is a major variants of competence-stimulating peptide (CSP), and it can regulate genetic transformation of S. pneumonia by modulating quorum sensing (QS). CSP1 can act as an antibacterial agent. | ||||||||||||||||||||
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References
- [1]. Yang Y, et, al. Structural Characterization of Competence-Stimulating Peptide Analogues Reveals Key Features for ComD1 and ComD2 Receptor Binding in Streptococcus pneumonia. Biochemistry. 2018 Sep 11;57(36):5359-5369. [Content Brief]
- [2]. Johnsborg O, et, al. A hydrophobic patch in the competence-stimulating Peptide, a pneumococcal competence pheromone, is essential for specificity and biological activity. J Bacteriol. 2006 Mar; 188(5): 1744-9. [Content Brief]
