174709-30-9
174709-30-9
Chemical Structure
BPIQ-I
Synonym(s): PD 159121
- CAS No.: 174709-30-9
- Formula:C16H12BrN5
- Molecular Weight:354.20
IUPAC Name: N-(3-bromophenyl)-3-methyl-3H-imidazo[4,5-g]quinazolin-8-amine
InChIKey: YAMAGACQNDAKFB-UHFFFAOYSA-N
SMILES: CN1C=NC2=CC3=C(NC4=CC=CC(Br)=C4)N=CN=C3C=C21
Biological Activity: BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively[1][2].
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BPIQ-I | BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively. | |||||||||||||||||||||
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References
- [1]. Rae JM, et al. Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors. Breast Cancer Res Treat. 2004 Jan;83(2):99-107. [Content Brief]
- [2]. Zhou Y, et al. Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules. Am J Physiol Renal Physiol. 2006 Aug;291(2):F358-67. [Content Brief]
Keywords
