1771691-32-7
1771691-32-7
Chemical Structure
Tyk2-IN-22-d3
- CAS No.: 1771691-32-7
- Formula:C20H19D3N8O3
- Molecular Weight:425.46
InChIKey: ROGKCOFPTFLUMN-FIBGUPNXSA-N
SMILES: COC1=C(C2=NN(C)N=N2)C=CC=C1NC3=CC(NC(C4CC4)=O)=NC=C3C(NC([2H])([2H])[2H])=O
Biological Activity: Tyk2-IN-22-d3 (Compound 1) is the deuterated analog of Tyk2-IN-22 (HY-168339). Tyk2-IN-22 (Compound A8) is a selective inhibitor for tyrosine kinase 2 (Tyk2), that it inhibits Tyk2, JAK1, and JAK3 with IC50s of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22 inhibits the downstream STAT5 phosphorylation[1][2].
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Tyk2-IN-22-d3 | Tyk2-IN-22-d3 (Compound 1) is the deuterated analog of Tyk2-IN-22 (HY-168339). Tyk2-IN-22 (Compound A8) is a selective inhibitor for tyrosine kinase 2 (Tyk2), that it inhibits Tyk2, JAK1, and JAK3 with IC50s of 9.7, 148.6, and 883.3 nM, respectively. Tyk2-IN-22 inhibits the downstream STAT5 phosphorylation. | |||||||||||||||||||||
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References
- [1]. AM Subbaiah M, et al. Prodrug Strategy to Address Impaired Oral Absorption of a Weakly Basic TYK2 Inhibitor Caused by a Gastric Acid-Reducing Agent[J]. Journal of Medicinal Chemistry, 2024, 67(22): 20664-20681. [Content Brief]
- [2]. Istanbullu H, et al. Discovery of selective TYK2 inhibitors: Design, synthesis, in vitro and in silico studies of promising hits with triazolopyrimidinone scaffold[J]. Bioorganic Chemistry, 2024, 148: 107430. [Content Brief]
Keywords
