1782070-22-7
1782070-22-7
Chemical Structure
PAT-505
- CAS No.: 1782070-22-7
- Formula:C23H18ClF2N3O2S
- Molecular Weight:473.92
IUPAC Name: 3-((6-chloro-2-cyclopropyl-1-(1-ethyl-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl)thio)-2-fluorobenzoic acid
InChIKey: BQMMCRXYIIKAOB-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=CC(SC2=C(C3CC3)N(C4=CN(CC)N=C4)C5=C2C=CC(Cl)=C5F)=C1F
Biological Activity: PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PAT-505 | 98.48% | PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma. | ||||||||||||||||||||
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PAT-505 (Standard) | PAT-505 (Standard) is the analytical standard of PAT-505 (HY-107781). This product is intended for research and analytical applications. PAT-505 is a potent, selective, noncompetitive and orally available autotaxin inhibitor, with an IC50 of 2 nM in Hep3B cells, 9.7 nM in human blood and 62 nM in mouse plasma. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.79
HY-123522PAT-048 -
Similarity Score 0.74
HY-145561Cudetaxestat -
Similarity Score 0.59
HY-126233PAT-347 -
Similarity Score 0.55
HY-126233APAT-347 sodium -
Similarity Score 0.49
HY-168930ATX inhibitor 25 -
Similarity Score 0.45
HY-111271L 888607 -
Similarity Score 0.45
HY-111271AL 888607 Racemate -
Similarity Score 0.45
HY-111271B(R)-L 888607 -
Similarity Score 0.44
HY-163656MAT2A inhibitor 5 -
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