1807367-80-1
Chemical Structure
Minodronic acid-d4
Synonym(s): YM-529-d4
- CAS No.: 1807367-80-1
- Formula:C9H8D4N2O7P2
- Molecular Weight:326.17
IUPAC Name: 2,2',2''-nitrilotris(N-(2,6-dimethylphenyl)acetamide)
InChIKey: VMMKGHQPQIEGSQ-RHQRLBAQSA-N
SMILES: O=P(O)(O)C(P(O)(O)=O)(O)CC1=CN=C2N1C([2H])=C([2H])C([2H])=C2[2H]
Biological Activity: Minodronic acid-d4 (YM-529-d4) is deuterium labeled Minodronic acid (HY-16322). Minodronic acid (YM-529) is an FPP synthase inhibitor with an IC50 of 3 nM, and also an antagonist of P2X2/3 receptors with an IC50 of 62.7 μM. Minodronic acid induces tumor cell apoptosis and inhibits cell growth. Minodronic acid also suppresses bone resorption. Minodronic acid can be used in research related to osteoporosis and cancer[1][2].
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Minodronic acid-d4 | Minodronic acid-d4 (YM-529-d4) is deuterium labeled Minodronic acid (HY-16322). Minodronic acid (YM-529) is an FPP synthase inhibitor with an IC50 of 3 nM, and also an antagonist of P2X2/3 receptors with an IC50 of 62.7 μM. Minodronic acid induces tumor cell apoptosis and inhibits cell growth. Minodronic acid also suppresses bone resorption. Minodronic acid can be used in research related to osteoporosis and cancer. | |||||||||||||||||||||
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Minodronic acid | 99.67% | Minodronic acid (YM-529) is an FPP synthase inhibitor with an IC50 of 3 nM, and also an antagonist of P2X2/3 receptors with an IC50 of 62.7 μM. Minodronic acid induces tumor cell apoptosis and inhibits cell growth. Minodronic acid also suppresses bone resorption. Minodronic acid can be used in research related to osteoporosis and cancer. | ||||||||||||||||||||
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Similarity Score 0.98
HY-16322AMinodronic acid hydrate -
Similarity Score 0.70
HY-117012NE58018 -
Similarity Score 0.66
HY-B0148RRisedronic acid (Standard) -
Similarity Score 0.64
HY-W779743NE58043 -
Similarity Score 0.64
HY-126825NE21650 -
Similarity Score 0.59
HY-B0119Risedronic acid sodium -
Similarity Score 0.58
HY-13777RZoledronic Acid (Standard) -
Similarity Score 0.58
HY-W777154Zoledronic acid-15N2,13C2 -
Similarity Score 0.58
HY-13777ARZoledronic acid monohydrate (Standard) -
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Sato K, et al. A third-generation bisphosphonate, minodronic acid (YM529), successfully prevented the growth of bladder cancer in vitro and in vivo. Br J Cancer. 2006 Nov 20;95(10):1354-61. [Content Brief]
