1808160-52-2
Chemical Structure
CF53
- CAS No.: 1808160-52-2
- Formula:C24H25N7O2
- Molecular Weight:443.50
IUPAC Name: N-(3-cyclopropyl-1-methyl-1H-pyrazol-5-yl)-7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-2-methyl-9H-pyrimido[4,5-b]indol-4-amine
InChIKey: JIYPVUCBRQNICX-UHFFFAOYSA-N
SMILES: COC1=C(C2=C(C)ON=C2C)C=C(NC3=C4C(NC5=CC(C6CC6)=NN5C)=NC(C)=N3)C4=C1
Biological Activity: CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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CF53 | 99.81% | CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo. | ||||||||||||||||||||
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Similarity Score 0.81
HY-122703BETi-211 -
Similarity Score 0.81
HY-107451PROTAC BET-binding moiety 1 -
Similarity Score 0.79
HY-112429HJB97 -
Similarity Score 0.61
HY-128977CD235 -
Similarity Score 0.61
HY-124596CD161 -
Similarity Score 0.61
HY-19549RX-37 -
Similarity Score 0.57
HY-114228PROTAC BET degrader-2 -
Similarity Score 0.56
HY-101519BETd-260 -
Similarity Score 0.53
HY-19760I-BET282 -
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