RX-37
RX-37 is a selective BET inhibitor. RX-37 binds to BET bromodomain proteins (BRD2, BRD3, and BRD4) with Ki values of 3.2-24.7 nM. RX-37 can be used for research of cancers.
For research use only. We do not sell to patients.
- CAS No.: 1627715-60-9
- Formula: C24H23N5O2
- Molecular Weight:413.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Ki: 11.1 nM, 11.7 nM, 7.3 nM, 3.2 nM, 24.7 nM, 12.2 nM (BRD2, BRD3, and BRD4 BD1 and BD2)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
>2000 nM
Compound: 18
|
Cytotoxicity against human K562 cells harboring BCR-ABL fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
Cytotoxicity against human K562 cells harboring BCR-ABL fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
|
[PMID: 26080064] |
| MOLM-13 | IC50 |
66 nM
Compound: 18
|
Cytotoxicity against human MOLM13 cells harboring MLL1 fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
Cytotoxicity against human MOLM13 cells harboring MLL1 fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
|
[PMID: 26080064] |
| MOLM-13 | IC50 |
66 nM
Compound: 6; RX-37
|
Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay
Growth inhibition of human MOLM13 cells after 4 days by WST-8 assay
|
[PMID: 28463487] |
| MV4-11 | IC50 |
20 nM
Compound: 18
|
Cytotoxicity against human MV4-11 cells harboring MLL1 fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
Cytotoxicity against human MV4-11 cells harboring MLL1 fusion gene assessed as growth inhibition after 4 days by CellTiter-Glo luminescent assay
|
[PMID: 26080064] |
| MV4-11 | IC50 |
20 nM
Compound: 6; RX-37
|
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
Growth inhibition of human MV4-11 cells after 4 days by WST-8 assay
|
[PMID: 28463487] |
Chemical Information
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CAS No. 1627715-60-9
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Molecular Weight 413.47
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Formula C24H23N5O2
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SMILES
COC1=CC2=C(NC3=C2C(C4=C(C)NN=C4C5CC5)=NC=C3)C=C1C6=C(C)ON=C6C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)