180916-16-9
Chemical Structure
Lasofoxifene
Synonym(s): CP-336156
- CAS No.: 180916-16-9
- Formula:C28H31NO2
- Molecular Weight:413.55
IUPAC Name: (5R,6S)-6-phenyl-5-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-5,6,7,8-tetrahydronaphthalen-2-ol
InChIKey: GXESHMAMLJKROZ-IAPPQJPRSA-N
SMILES: OC1=CC=C2[C@@H](C3=CC=C(OCCN4CCCC4)C=C3)[C@@H](C5=CC=CC=C5)CCC2=C1
Biological Activity: Lasofoxifene (CP-336156) is an orally active and selective estrogen receptor modulator (SERM). Lasofoxifene exhibits an anti-osteoporotic function and also inhibits primary tumor growth and metastases. Lasofoxifene can be used for research of breast cancer and postmenopausal osteoporosis[1][2].
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Lasofoxifene | 99.27% | Lasofoxifene (CP-336156) is an orally active and selective estrogen receptor modulator (SERM). Lasofoxifene exhibits an anti-osteoporotic function and also inhibits primary tumor growth and metastases. Lasofoxifene can be used for research of breast cancer and postmenopausal osteoporosis. | ||||||||||||||||||||
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Lasofoxifene (Standard) | ≥98% | Lasofoxifene (Standard) is the analytical standard of Lasofoxifene. This product is intended for research and analytical applications. Lasofoxifene (CP-336156) is an orally active and selective estrogen receptor modulator (SERM). Lasofoxifene exhibits an anti-osteoporotic function and also inhibits primary tumor growth and metastases. Lasofoxifene can be used for research of breast cancer and postmenopausal osteoporosis. | ||||||||||||||||||||
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Similarity Score 0.84
HY-A0038Lasofoxifene tartrate -
Similarity Score 0.75
HY-U00216NNC45-0781 -
Similarity Score 0.65
HY-172067ER ligand-9 -
Similarity Score 0.64
HY-122359Levormeloxifene -
Similarity Score 0.64
HY-122359Arel-Levormeloxifene -
Similarity Score 0.61
HY-145716Nafoxidine -
Similarity Score 0.60
HY-W040046Nafoxidine hydrochloride -
Similarity Score 0.58
HY-122359BLevormeloxifene fumarate -
Similarity Score 0.57
HY-10830APBPE hydrochloride -
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References
- [1]. Andersson A, et al. Selective oestrogen receptor modulators lasofoxifene and bazedoxifene inhibit joint inflammation and osteoporosis in ovariectomised mice with collagen-induced arthritis. Rheumatology (Oxford). 2016 Mar;55(3):553-63. [Content Brief]
- [2]. Andreano KJ, et al. The Dysregulated Pharmacology of Clinically Relevant ESR1 Mutants is Normalized by Ligand-activated WT Receptor. Mol Cancer Ther. 2020 Jul. 19(7):1395-1405. [Content Brief]
