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  2. Estrogen Receptor/ERR
  3. NNC45-0781

NNC45-0781 

Cat. No.: HY-U00216
Handling Instructions

NNC45-0781 is a tissue-selective estrogen partial-agonist.

For research use only. We do not sell to patients.

NNC45-0781 Chemical Structure

NNC45-0781 Chemical Structure

CAS No. : 207277-66-5

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Description

NNC45-0781 is a tissue-selective estrogen partial-agonist.

IC50 & Target

Estrogen Receptor[1]

In Vivo

NNC45-0781 (NNC 45-0781) shows that it is a very promising tissue-selective estrogen agonist. Total serum cholesterol is significantly increased in the vehicle-treated group as compared to the sham animals. All of the animals receiving NNC45-0781 at doses of 10 nmol/g or higher, has significantly lower levels of total serum cholesterol as compared to the vehicle treated group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

415.52

Formula

C₂₇H₂₉NO₃

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[1]

Rats[1]
Female Sprague-Dawley rats, 12 weeks of age, weighing approximately 250 g are used in these studies.The pharmacological properties of NNC45-0781 (NNC 45-0781) are studied through a series of in vivo experiments. Activity of orally administered NNC45-0781 (1,10, 50 and 100 nmol/g) on total serum cholesterol in the ovariectomized rat.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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NNC45-0781
Cat. No.:
HY-U00216
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