1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. NNC45-0781


Cat. No.: HY-U00216
Handling Instructions

NNC45-0781 is a tissue-selective estrogen partial-agonist.

For research use only. We do not sell to patients.

NNC45-0781 Chemical Structure

NNC45-0781 Chemical Structure

CAS No. : 207277-66-5

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This product is a controlled substance and not for sale in your territory.

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NNC45-0781 is a tissue-selective estrogen partial-agonist.

IC50 & Target

Estrogen Receptor[1]

In Vivo

NNC45-0781 (NNC 45-0781) shows that it is a very promising tissue-selective estrogen agonist. Total serum cholesterol is significantly increased in the vehicle-treated group as compared to the sham animals. All of the animals receiving NNC45-0781 at doses of 10 nmol/g or higher, has significantly lower levels of total serum cholesterol as compared to the vehicle treated group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight





OC1=CC=C([[email protected]@H](C2=CC=C(OCCN3CCCC3)C=C2)[[email protected]@H](C4=CC=CC=C4)CO5)C5=C1


Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
Animal Administration

Female Sprague-Dawley rats, 12 weeks of age, weighing approximately 250 g are used in these studies.The pharmacological properties of NNC45-0781 (NNC 45-0781) are studied through a series of in vivo experiments. Activity of orally administered NNC45-0781 (1,10, 50 and 100 nmol/g) on total serum cholesterol in the ovariectomized rat.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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