NNC45-0781

Cat. No.: HY-U00216: FAQs
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NNC45-0781 is a tissue-selective estrogen partial-agonist.

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NNC45-0781 Chemical Structure

CAS No. : 207277-66-5

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Customer Review

Description	NNC45-0781 is a tissue-selective estrogen partial-agonist.
IC₅₀ & Target	Estrogen Receptor^[1]
In Vivo	NNC45-0781 (NNC 45-0781) shows that it is a very promising tissue-selective estrogen agonist. Total serum cholesterol is significantly increased in the vehicle-treated group as compared to the sham animals. All of the animals receiving NNC45-0781 at doses of 10 nmol/g or higher, has significantly lower levels of total serum cholesterol as compared to the vehicle treated group^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	415.52
Formula	C₂₇H₂₉NO₃
CAS No.	207277-66-5
SMILES	OC1=CC=C([C@@H](C2=CC=C(OCCN3CCCC3)C=C2)[C@@H](C4=CC=CC=C4)CO5)C5=C1
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (273 KB) Handling Instructions (2659 KB)
References	[1]. Bury PS, et al. Synthesis and pharmacological evaluation of novel cis-3,4-diaryl-hydroxychromanes as high affinity partial agonists for the estrogen receptor. Bioorg Med Chem. 2002 Jan;10(1):125-45. [Content Brief]

Animal Administration
^[1]

Rats^[1]
Female Sprague-Dawley rats, 12 weeks of age, weighing approximately 250 g are used in these studies.The pharmacological properties of NNC45-0781 (NNC 45-0781) are studied through a series of in vivo experiments. Activity of orally administered NNC45-0781 (1,10, 50 and 100 nmol/g) on total serum cholesterol in the ovariectomized rat.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Bury PS, et al. Synthesis and pharmacological evaluation of novel cis-3,4-diaryl-hydroxychromanes as high affinity partial agonists for the estrogen receptor. Bioorg Med Chem. 2002 Jan;10(1):125-45. [Content Brief]

NNC45-0781 Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NNC45-0781207277-66-5Estrogen Receptor/ERRInhibitorinhibitorinhibit

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NNC45-0781

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