18304-79-5
Chemical Structure
Bax agonist 1
- CAS No.: 18304-79-5
- Formula:C8H16N4
- Molecular Weight:168.24
IUPAC Name: 1,3,6,8-tetraazatricyclo[6.2.1.13,6]dodecane
InChIKey: ZBFHXDNNFOOFLY-UHFFFAOYSA-N
SMILES: N12CN(CC2)CN(C3)CCN3C1
Biological Activity: Bax agonist 1 (compound SMBA2) is a Bax agonist (Ki=57.2 nM). Bax agonist 1 induces Bax conformational changes by blocking S184 phosphorylation, promoting Bax insertion into the mitochondrial membrane and forming Bax oligomers, which induce cytochrome c release and apoptosis in malignant cancer cells expressing Bax. Bax agonist 1 can be used in lung cancer research[1].
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Bax agonist 1 | Bax agonist 1 (compound SMBA2) is a Bax agonist (Ki=57.2 nM). Bax agonist 1 induces Bax conformational changes by blocking S184 phosphorylation, promoting Bax insertion into the mitochondrial membrane and forming Bax oligomers, which induce cytochrome c release and apoptosis in malignant cancer cells expressing Bax. Bax agonist 1 can be used in lung cancer research. | |||||||||||||||||||||
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Keywords
