1836209-98-3
Chemical Structure
DETD-35
- CAS No.: 1836209-98-3
- Formula:C27H24O6
- Molecular Weight:444.48
InChIKey: JPEGNKAXYSEQDC-BEBSEGTMSA-N
SMILES: O=C(O[C@H]1[C@H](C(C(O2)=O)=C)[C@@H]2CC(C(O3)=O)=C[C@H]3C/C(C)=C/1)CC4=CC=CC5=C4C=CC=C5
Biological Activity: DETD-35 is an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways, which promotes cancer cell apoptosis (Apoptosis) and reduces cancer cell resistance to Vemurafenib (HY-12057). The IC50 values of DETD-35 against wild-type and mutant melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c are 2.7, 6.0, 3.9, 3.1, and 2.5 μM, respectively. DETD-35 holds promise for research in the field of anti-melanoma therapy[1].
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DETD-35 | DETD-35 is an inhibitor of the MEK-ERK, Akt, and STAT3 signaling pathways, which promotes cancer cell apoptosis (Apoptosis) and reduces cancer cell resistance to Vemurafenib (HY-12057). The IC50 values of DETD-35 against wild-type and mutant melanoma cell lines B16-F10, MeWo, SK-MEL-2, A2058c, and A375c are 2.7, 6.0, 3.9, 3.1, and 2.5 μM, respectively. DETD-35 holds promise for research in the field of anti-melanoma therapy. | |||||||||||||||||||||
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Keywords
