184576-87-2
184576-87-2
Chemical Structure
ROS 234
- CAS No.: 184576-87-2
- Formula:C13H15N5
- Molecular Weight:241.29
IUPAC Name: N-(3-(1H-imidazol-5-yl)propyl)-1H-benzo[d]imidazol-2-amine
InChIKey: XAJKXTPKZFCYPN-UHFFFAOYSA-N
SMILES: C1(NCCCC2=CN=CN2)=NC3=CC=CC=C3N1
Biological Activity: ROS 234 is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access[1][2].
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ROS 234 | ROS 234 is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access. | |||||||||||||||||||||
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References
- [1]. Ballabeni V, et al. CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm Res. 2002 Apr;51 Suppl 1:S55-6. [Content Brief]
- [2]. Mor M, et al. Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg Med Chem. 2004 Feb 15;12(4):663-74. [Content Brief]
