18588-57-3
18588-57-3
Chemical Structure
Etoprine
- CAS No.: 18588-57-3
- Formula:C12H12Cl2N4
- Molecular Weight:283.16
IUPAC Name: 5-(3,4-dichlorophenyl)-6-ethylpyrimidine-2,4-diamine
InChIKey: PXLPCZJACKUXGP-UHFFFAOYSA-N
SMILES: ClC1=CC=C(C=C1Cl)C=2C(=NC(=NC2CC)N)N
Biological Activity: Etoprine is a potent orally active dihydrofolate reductase (DHFR) inhibitor. Etoprine competitively inhibits testicular DHFR to disrupt tetrahydrofolate and DNA synthesis in rapidly dividing cells. Etoprine acts as an antifertility agent in male mice and reduces fecundity in male rats[1][2].
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Etoprine | Etoprine is a potent orally active dihydrofolate reductase (DHFR) inhibitor. Etoprine competitively inhibits testicular DHFR to disrupt tetrahydrofolate and DNA synthesis in rapidly dividing cells. Etoprine acts as an antifertility agent in male mice and reduces fecundity in male rats. | |||||||||||||||||||||
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References
- [1]. Malik NS, et al. The contraceptive effects of etoprine on male mice and rats. J Androl. 1995;16(2):169-174. [Content Brief]
- [2]. Bunyarataphan S, et al. Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays. Antimicrob Agents Chemother. 2006;50(11):3631-3637. [Content Brief]
Keywords
