186692-45-5
186692-45-5
Chemical Structure
(S)-Roscovitine
Synonym(s): (S)-Seliciclib; (S)-CYC202
- CAS No.: 186692-45-5
- Formula:C19H26N6O
- Molecular Weight:354.45
IUPAC Name: (S)-2-((6-(benzylamino)-9-isopropyl-9H-purin-2-yl)amino)butan-1-ol
InChIKey: BTIHMVBBUGXLCJ-HNNXBMFYSA-N
SMILES: CC[C@H](NC1=NC(NCC2=CC=CC=C2)=C3N=CN(C(C)C)C3=N1)CO
Biological Activity: (S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S)-Roscovitine shows neuroprotective efficacy. (S)-Roscovitine has the potential for the research of stroke[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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(S)-Roscovitine | 99.15% | (S)-Roscovitine ((S)-Seliciclib; (S)-CYC202) is a potent and cross the blood-brain barrier CDKs inhibitor. (S)-Roscovitine shows neuroprotective efficacy. (S)-Roscovitine has the potential for the research of stroke. | ||||||||||||||||||||
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References
- [1]. Le Roy L, et al. Cellular and Molecular Mechanisms of R/S-Roscovitine and CDKs Related Inhibition under Both Focal and Global Cerebral Ischemia: A Focus on Neurovascular Unit and Immune Cells. Cells. 2021 Jan 8;10(1):104. [Content Brief]
- [2]. Menn B, et al. Delayed treatment with systemic (S)-roscovitine provides neuroprotection and inhibits in vivo CDK5 activity increase in animal stroke models. PLoS One. 2010 Aug 12;5(8):e12117. [Content Brief]
Keywords
