192880-96-9
Chemical Structure
HT1171
- CAS No.: 192880-96-9
- Formula:C7H4N2O4S2
- Molecular Weight:244.25
IUPAC Name: 5-(5-methyl-4-nitrothiophen-2-yl)-1,3,4-oxathiazol-2-one
InChIKey: ILBBOKHACYTXRK-UHFFFAOYSA-N
SMILES: O=C1OC(C2=CC([N+]([O-])=O)=C(C)S2)=NS1
Biological Activity: HT1171 is a potent and selective inhibitor of mycobacterium tuberculosis proteasome. HT1171 shows strong anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv with an MIC90 of 2 μg/mL and an MIC of 4 μg/mL. When HT1171 concentration is 100 μM, the inhibition rate of human normal hepatocytes L02 is 53.8%. HT1171 can be used in the research of antitubercular agent[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
HT1171 | 99.33% | HT1171 is a potent and selective inhibitor of mycobacterium tuberculosis proteasome. HT1171 shows strong anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv with an MIC90 of 2 μg/mL and an MIC of 4 μg/mL. When HT1171 concentration is 100 μM, the inhibition rate of human normal hepatocytes L02 is 53.8%. HT1171 can be used in the research of antitubercular agent. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Yang J, et al. 3H-1,2,4-Dithiazol-3-one compounds as novel potential affordable antitubercular agents. Bioorg Med Chem Lett. 2013 Mar 1;23(5):1424-7. [Content Brief]
- [2]. Almeleebia TM, et al. Identification of New Mycobacterium tuberculosis Proteasome Inhibitors Using a Knowledge-Based Computational Screening Approach. Molecules. 2021 Apr 16;26(8):2326. [Content Brief]
Keywords
