1949802-49-6
1949802-49-6
Chemical Structure
PI3K/mTOR Inhibitor-1
- CAS No.: 1949802-49-6
- Formula:C18H22FN5O3S
- Molecular Weight:407.46
IUPAC Name: (S)-4-fluoro-5-(2-(3-methylmorpholino)-6-(1-(methylsulfonyl)cyclopropyl)pyrimidin-4-yl)pyridin-2-amine
InChIKey: LBIPJQHFIZPQHA-NSHDSACASA-N
SMILES: NC1=CC(F)=C(C2=CC(C3(CC3)S(=O)(C)=O)=NC(N4[C@@H](C)COCC4)=N2)C=N1
Biological Activity: PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual PI3K/mTOR inhibitor with IC50s of 20/376/204/46 nM and 186 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ and mTOR, respectively[1]. Antitumor activity[1].
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PI3K/mTOR Inhibitor-1 | PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual PI3K/mTOR inhibitor with IC50s of 20/376/204/46 nM and 186 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ and mTOR, respectively. Antitumor activity. | |||||||||||||||||||||
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