196391-82-9
Chemical Structure
Prosaptide Tx14(A)
- CAS No.: 196391-82-9
- Formula:C69H110N16O26
- Molecular Weight:1579.70
IUPAC Name: (2S,5S,8S,11S,14S,17S,20S,23S,26S,29S)-23,26-bis(2-amino-2-oxoethyl)-29-((2S,3S)-2-((S)-2-((R)-2-((2S,3R)-2-amino-3-hydroxybutanamido)propanamido)-4-methylpentanamido)-3-methylpentanamido)-8-((S)-sec-butyl)-11,14-bis(2-carboxyethyl)-2-(4-hydroxybenzyl)-17-((R)-1-hydroxyethyl)-5-isobutyl-20-methyl-4,7,10,13,16,19,22,25,28-nonaoxo-3,6,9,12,15,18,21,24,27-nonaazahentriacontanedioic acid
InChIKey: SMUKRAODILXPSW-SRWCCNGVSA-N
SMILES: OC(C=C1)=CC=C1C[C@@H](C(O)=O)NC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](CC(N)=O)NC([C@H](CC(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CC(C)C)NC([C@@H](C)NC([C@@H](N)[C@H](O)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Biological Activity: Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Prosaptide Tx14(A) | 99.73% | Prosaptide Tx14(A), a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) increases both ERK1 and ERK2 phosphorylation in Schwann cells. | ||||||||||||||||||||
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References
- [1]. Meyer RC, et al. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci U S A. 2013;110(23):9529-9534. [Content Brief]
- [2]. Campana WM, et al. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 1998;12(3):307-314. [Content Brief]
