197172-76-2
197172-76-2
Chemical Structure
Cyclopeptide-5
Synonym(s): EMD 270179
- CAS No.: 197172-76-2
- Formula:C28H40N8O7
- Molecular Weight:600.67
IUPAC Name: 2-((9R,12S,18S)-9-benzyl-18-(3-guanidinopropyl)-8,11,14,17,20-pentaoxo-7,10,13,16,19-pentaazaspiro[5.14]icosan-12-yl)acetic acid
InChIKey: ROFCWWUBJHHVGZ-ZCNNSNEGSA-N
SMILES: O=C1C2(CCCCC2)NC([C@H](NC([C@@H](NC(CNC([C@@H](N1)CCCNC(N)=N)=O)=O)CC(O)=O)=O)CC3=CC=CC=C3)=O
Biological Activity: Cyclopeptide-5 (EMD 270179) is an αvβ3 antagonist that can improve PAF-induced increased adhesion of sickle red blood cells, capillary post-obstruction, and enhance blood flow dynamics. Cyclopeptide-5 also has cytotoxic effects[1][2].
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Cyclopeptide-5 | Cyclopeptide-5 (EMD 270179) is an αvβ3 antagonist that can improve PAF-induced increased adhesion of sickle red blood cells, capillary post-obstruction, and enhance blood flow dynamics. Cyclopeptide-5 also has cytotoxic effects. | |||||||||||||||||||||
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References
- [1]. M Abo-Ghalia, et al. Synthesis and investigation of a new cyclo (Nalpha-dipicolinoyl) pentapeptide of a breast and CNS cytotoxic activity and an ionophoric specificity. Amino Acids. 2004 Jun;26(3):283-9. [Content Brief]
- [2]. Eileen M Finnegan, et al. Small-molecule cyclic alpha V beta 3 antagonists inhibit sickle red cell adhesion to vascular endothelium and vasoocclusion. Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1038-45. [Content Brief]
