19728-88-2
Chemical Structure
Methiothepin maleate
Synonym(s): Metitepine maleate; Ro-8-6837 maleate
- CAS No.: 19728-88-2
- Formula:C24H28N2O4S2
- Molecular Weight:472.62
IUPAC Name: 1-methyl-4-(8-(methylthio)-10,11-dihydrodibenzo[b,f]thiepin-10-yl)piperazine maleate
InChIKey: IWDBEHWZGDSFHR-BTJKTKAUSA-N
SMILES: CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(SC)C=C24)CC1.OC(/C=C\C(O)=O)=O
Biological Activity: Methiothepin maleate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C).
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Methiothepin maleate | Methiothepin maleate is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C). | |||||||||||||||||||||
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Keywords
