Methiothepin maleate (Synonyms: Metitepine maleate; Ro-8-6837 maleate)

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Methiothepin maleate is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).

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Methiothepin maleate Chemical Structure

CAS No. : 19728-88-2

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Other In-stock Forms of Methiothepin maleate:

Methiothepin mesylate

Other Forms of Methiothepin maleate:

Methiothepin mesylate In-stock

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Description	Methiothepin maleate is a potent and non-selective 5-HT₂ receptor antagonist, with pK_ds of 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D), 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), and 8.99 (5-HT₇), and pK_is of 8.50 (5HT_2A), 8.68 (5HT_2B), and 8.35 (5HT_2C).
IC₅₀ & Target	pKd: 7.10 (5-HT_1A), 7.28 (5HT_1B), 7.56 (5HT_1C), 6.99 (5HT_1D)^[1], 7.0 (5-HT_5A), 7.8 (5-HT_5B), 8.74 (5-HT₆), 8.99 (5-HT₇)^[3] pKi: 8.50 (5-HT_2A), 8.68 (5-HT_2B), 8.35 (5-HT_2C)^[2]
In Vitro	Methiothepin maleate is a 5-HT receptor antagonist, with pK_ds of 7.10, 7.28, 7.56, and 6.99 for 5-HT_1A, 5HT_1B, 5HT_1C, 5HT_1D^[1]. Methiothepin mesylate also shows pK_ds of 7.0, 7.8, 8.74, and 8.99 for 5-HT_5A, 5-HT_5B, 5-HT₆, and 5-HT₇, respectively^[2]. Methiothepin exhibits high affinity at 5-HT_2A, 5HT_2B, and 5HT_2C with pK_is of 8.50, 8.68, and 8.35, respectively^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Methiothepin maleate Related Antibodies
Molecular Weight	472.62
Formula	C₂₄H₂₈N₂O₄S₂
CAS No.	19728-88-2
SMILES	CN1CCN(C2CC3=CC=CC=C3SC4=CC=C(SC)C=C24)CC1.OC(/C=C\C(O)=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (275 KB) Handling Instructions (2659 KB)

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methiothepin19728-88-2MetitepineRo-8-6837Inhibitorinhibitorinhibit

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