19767-45-4
19767-45-4
Chemical Structure
Sodium 2-mercaptoethanesulfonate
Synonym(s): Mesnum
- CAS No.: 19767-45-4
- Formula:C2H5NaO3S2
- Molecular Weight:164.18
IUPAC Name: sodium 2-mercaptoethane-1-sulfonate
InChIKey: XOGTZOOQQBDUSI-UHFFFAOYSA-M
SMILES: SCCS(=O)(O[Na])=O
Biological Activity: Sodium 2-mercaptoethanesulfonate (Mesnum) is a thiol-containing urinary tract protective agent and aldehyde scavenger that detoxifies acrolein via its thiol group to form an inert thioether excreted in urine, and competitively inhibits human myeloperoxidase, thereby mitigating Cyclophosphamide (HY-17420)-induced cytogenetic damage. Sodium 2-mercaptoethanesulfonate can be used for research on hemorrhagic cystitis[1][2][3][4][5][6][7][8][9].
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Sodium 2-mercaptoethanesulfonate | 99.92% | Sodium 2-mercaptoethanesulfonate (Mesnum) is a thiol-containing urinary tract protective agent and aldehyde scavenger that detoxifies acrolein via its thiol group to form an inert thioether excreted in urine, and competitively inhibits human myeloperoxidase, thereby mitigating Cyclophosphamide (HY-17420)-induced cytogenetic damage. Sodium 2-mercaptoethanesulfonate can be used for research on hemorrhagic cystitis. | ||||||||||||||||||||
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Sodium 2-mercaptoethanesulfonate (Standard) | 99.52% | Sodium 2-mercaptoethanesulfonate (Standard) is the analytical standard of Sodium 2-mercaptoethanesulfonate. This product is intended for research and analytical applications. Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide. | ||||||||||||||||||||
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2-Mercaptoethanesulfonate-d4 sodium | 2-Mercaptoethanesulfonate-d4 sodium (Mesnum-d4 sodium) is the deuterium labeled Sodium 2-mercaptoethanesulfonate (HY-13679). Mesna (Sodium 2-mercaptoethanesulfonate) is an antioxidant which has cytoprotective effects. Mesna is widely used as a systemic protective agent against chemotherapy toxicity. Mesna is also used to reduce hemorrhagic cystitis induced by cyclophosphamide. | |||||||||||||||||||||
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References
- [1]. Wilmer JL, et al. Attenuation of cytogenetic damage by 2-mercaptoethanesulfonate in cultured human lymphocytes exposed to cyclophosphamide and its reactive metabolites. Cancer research. 1986 Jan;46(1):203-10.
- [2]. Jiang Q. Continuous IV infusion of MESNA can prevent hemorrhagic cystitis in HSCT and retain MESNA concentration in urine. Bone Marrow Transplantation. 2015 Nov;50(11):1490-2.
- [3]. Jeelani R, et al. Mesna (2-mercaptoethane sodium sulfonate) functions as a regulator of myeloperoxidase. Free radical biology & medicine. 2017 Sep;110:54-62.
- [4]. Wood PL, et al. Cellular thiol pools are responsible for sequestration of cytotoxic reactive aldehydes: central role of free cysteine and cysteamine. Brain research. 2007 Jul 16;1158:158-63.
- [5]. Kali G, et al. Enhanced Mucoadhesion of Thiolated β-Cyclodextrin by S-Protection with 2-Mercaptoethanesulfonic Acid. ACS omega. 2024 Feb 06;9(5):5819-5828.
- [6]. Stabler SP, et al. Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine. Free radical biology & medicine. 2009 Oct 15;47(8):1147-53.
- [7]. Balch WE, et al. Transport of coenzyme M (2-mercaptoethanesulfonic acid) in Methanobacterium ruminantium. Journal of bacteriology. 1979 Jan;137(1):264-73.
- [8]. Batista CK, et al. A model of hemorrhagic cystitis induced with acrolein in mice. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2006 Nov;39(11):1475-81.
- [9]. Ali SA, et al. Comparision of uroprotective activity of reduced glutathione with mesna in ifosfamide induced hemorrhagic cystitis in rats. Indian journal of pharmacology. 2014;46(1):105-8.
