2034-72-2
Chemical Structure
Stigmasta-3,5-dien-7-one
- CAS No.: 2034-72-2
- Formula:C29H46O
- Molecular Weight:410.67
InChIKey: LCFUUGFUQQAYMY-CJAQKTMASA-N
SMILES: O=C1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CC[C@@H](CC)C(C)C)(CC[C@]2([H])[C@@]4(C(C=CCC4)=C1)C)C
Biological Activity: Stigmasta-3,5-dien-7-one is a steroid compound that can be isolated from Harrisonia abyssinica. Stigmasta-3,5-dien-7-one blocks the NF-κB signaling pathway via down-regulation of phospho-p38 mitogen-activated protein kinase and phosphorylation and degradation of inhibitor of NF-κB α. Stigmasta-3,5-dien-7-one reduces LPS (HY-D1056)-induced nitric oxide, PGE2, and pro-inflammatory cytokine levels in macrophages. Stigmasta-3,5-dien-7-one can be used for inflammation diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Stigmasta-3,5-dien-7-one | 99.84% | Stigmasta-3,5-dien-7-one is a steroid compound that can be isolated from Harrisonia abyssinica. Stigmasta-3,5-dien-7-one blocks the NF-κB signaling pathway via down-regulation of phospho-p38 mitogen-activated protein kinase and phosphorylation and degradation of inhibitor of NF-κB α. Stigmasta-3,5-dien-7-one reduces LPS (HY-D1056)-induced nitric oxide, PGE2, and pro-inflammatory cytokine levels in macrophages. Stigmasta-3,5-dien-7-one can be used for inflammation diseases. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.89
HY-168758Delta3,5-cholestadien-7-one -
Similarity Score 0.78
HY-W587816Stigmasta-3,5-diene -
Similarity Score 0.78
HY-N12163Stigmast-5-ene-3,7-dione -
Similarity Score 0.77
HY-N12521(3β,24S)-3-Hydroxystigmast-5-en-7-one -
Similarity Score 0.77
HY-N27577-Ketositosterol -
Similarity Score 0.74
HY-N1238β-Sitostenone -
Similarity Score 0.74
HY-N12996Sitosterone -
Similarity Score 0.72
HY-N1221Stigmast-4-en-3,6-dione -
Similarity Score 0.71
HY-W780517(3β)-3-Hydroxyergost-5-en-7-one -
Explore the MedChemAI to find more analogs
References
- [1]. Park SJ, et al. Anti-inflammatory Steroid from Phragmitis rhizoma Modulates LPS-Mediated Signaling Through Inhibition of NF-κB Pathway. Inflammation. 2016;39(2):727-734. [Content Brief]
- [2]. Baldé AM, et al. Steroids from Harrisonia abyssinica. Planta Med. 2000;66(1):67-69. [Content Brief]
- [3]. Szakiel A, et al. Triterpenoid content of berries and leaves of bilberry Vaccinium myrtillus from Finland and Poland. J Agric Food Chem. 2012;60(48):11839-11849. [Content Brief]
