207556-07-8
Chemical Structure
MPP+-d3 iodide
- CAS. Nr.: 207556-07-8
- Formula:C12H9D3IN
- Molecular Weight:300.15
IUPAC Name: 1-(methyl-d3)-4-phenylpyridin-1-ium iodide
InChIKey: RFDFRDXIIKROAI-NIIDSAIPSA-M
SMILES: [2H]C([2H])([2H])[N+]1=CC=C(C2=CC=CC=C2)C=C1.[I-]
Biological Activity: MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].
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MPP+-d3 iodide | 99.21% | MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT). | ||||||||||||||||||||
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MPP+ iodide (Standard) | ≥98% | MPP+ iodide (Standard) is the analytical standard of MPP+ iodide (HY-W008719). This product is intended for research and analytical applications. MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of ParKinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT). | ||||||||||||||||||||
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MPP+ iodide | 99.96% | MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT). | ||||||||||||||||||||
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Similarity Score 0.85
HY-W1123781-Methyl-4,4'-bipyridinium chloride -
Similarity Score 0.82
HY-W017077S4-Methylbiphenyl-d3 -
Similarity Score 0.81
HY-W0170774-Methylbiphenyl -
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HY-W106014S[1,1'-Biphenyl]-3-amine-13C6 hydrochloride -
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HY-W0169833-Phenylphenol -
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HY-41826R4-Bromobiphenyl (Standard) -
Similarity Score 0.79
HY-W0080303-Aminobiphenyl -
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HY-1295654-Methoxybiphenyl -
Similarity Score 0.79
HY-W002820R2-Amino-5-phenylpyridine (Standard) -
Explore the MedChemAI to find more analogs
![[1,1'-Biphenyl]-3-amine-<sup>13</sup>C<sub>6</sub> hydrochloride Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w106014s.gif)
References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394. [Content Brief]
