2097117-06-9
Chemical Structure
Lu AF27139
- CAS No.: 2097117-06-9
- Formula:C21H19ClF3N5O2S
- Molecular Weight:497.92
IUPAC Name: (S)-N-(2-(4-chlorophenyl)-2-morpholinoethyl)-2-(pyrimidin-2-yl)-4-(trifluoromethyl)thiazole-5-carboxamide
InChIKey: FGPQIEDRTXLBES-OAHLLOKOSA-N
SMILES: ClC(C=C1)=CC=C1[C@H](N2CCOCC2)CNC(C3=C(C(F)(F)F)N=C(C4=NC=CC=N4)S3)=O
Biological Activity: Lu AF27139 is a potent, selective, and orally active antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 has rodent-active and CNS-penetrant character. Lu AF27139 has the potential for the research of CNS diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Lu AF27139 | 99.71% | Lu AF27139 is a potent, selective, and orally active antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 has rodent-active and CNS-penetrant character. Lu AF27139 has the potential for the research of CNS diseases. | ||||||||||||||||||||
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Similarity Score 0.47
HY-100501RM2698 (Standard) -
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HY-146670KDM5B-IN-3 -
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HY-181487FAK activator-1 -
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HY-101765RGW 833972A (Standard) -
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HY-120188CC618 -
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HY-14167GW842166X -
Similarity Score 0.45
HY-19852KRP-105 -
Similarity Score 0.45
HY-180365GW 833972A free base -
Similarity Score 0.45
HY-134188JNJ-54717793 -
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