2098896-13-8
Chemical Structure
HDAC-IN-54
- CAS No.: 2098896-13-8
- Formula:C24H32N4O4
- Molecular Weight:440.54
IUPAC Name: N-(2-(benzylamino)-2-oxoethyl)-4-(dimethylamino)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide
InChIKey: LLBWUNKGCADDKQ-UHFFFAOYSA-N
SMILES: O=C(NO)CCCCCN(C(=O)C1=CC=C(C=C1)N(C)C)CC(=O)NCC=2C=CC=CC2
Biological Activity: HDAC-IN-54 is a HDAC inhibitor with an IC50 of 25 nM against human HDAC1, 66 nM against HDAC2, 6.5 nM against HDAC3, and 281 nM against HDAC6. HDAC-IN-54 induces acetylation of α-tubulin and histone H3. HDAC-IN-54 acts synergistically with cisplatin to induce cancer cell apoptosis. HDAC-IN-54 can be used in research related to head and neck cancer, ovarian cancer, and tongue squamous cell carcinoma[1].
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HDAC-IN-54 | HDAC-IN-54 is a HDAC inhibitor with an IC50 of 25 nM against human HDAC1, 66 nM against HDAC2, 6.5 nM against HDAC3, and 281 nM against HDAC6. HDAC-IN-54 induces acetylation of α-tubulin and histone H3. HDAC-IN-54 acts synergistically with cisplatin to induce cancer cell apoptosis. HDAC-IN-54 can be used in research related to head and neck cancer, ovarian cancer, and tongue squamous cell carcinoma. | |||||||||||||||||||||
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