2101645-33-2
2101645-33-2
Chemical Structure
Frespaciguat
Synonym(s): MK-5475; sGC activator 1
- CAS No.: 2101645-33-2
- Formula:C27H22ClF5N6O3
- Molecular Weight:608.95
InChIKey: BAFUFNSAYGCZIC-VWLOTQADSA-N
SMILES: C[C@]1(C2=CC=C(C=C2)CCC(O)=O)C3=C(N)N=C(C4=NN(CCC(F)(F)C(F)(F)F)C5=CC(Cl)=CC=C45)N=C3NC1=O
Biological Activity: Frespaciguat (MK-5475) is an orally active soluble guanylate cyclase (sGC) activator with a Kd of 0.05 nM and a Ki of 0.15 nM. Frespaciguat increases cyclic guanosine monophosphate production and promotes vasodilation. Frespaciguat can be used in research on pulmonary hypertension associated with chronic obstructive pulmonary disease (ph-copd) and hypertension[1].
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Frespaciguat | Frespaciguat (MK-5475) is an orally active soluble guanylate cyclase (sGC) activator with a Kd of 0.05 nM and a Ki of 0.15 nM. Frespaciguat increases cyclic guanosine monophosphate production and promotes vasodilation. Frespaciguat can be used in research on pulmonary hypertension associated with chronic obstructive pulmonary disease (ph-copd) and hypertension. | |||||||||||||||||||||
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