2101945-93-9
Chemical Structure
Enpatoran hydrochloride
Synonym(s): M5049 hydrochloride
- CAS No.: 2101945-93-9
- Formula:C16H16ClF3N4
- Molecular Weight:356.77
IUPAC Name: 5-((3R,5S)-3-amino-5-(trifluoromethyl)piperidin-1-yl)quinoline-8-carbonitrile hydrochloride
InChIKey: OHYZGHQWGHDMRP-ZVWHLABXSA-N
SMILES: [H]Cl.N#CC(C=C1)=C(N=CC=C2)C2=C1N3C[C@@H](C(F)(F)F)C[C@@H](N)C3
Biological Activity: Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3, TLR4 and TLR9. Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Enpatoran hydrochloride | 99.42% | Enpatoran (M5049) hydrochloride is a potent, orally active and dual TLR7/8 inhibitor with IC50s of 11.1 nM and 24.1 nM in HEK293 cells, respectively. Enpatoran hydrochloride is inactive against TLR3, TLR4 and TLR9. Enpatoran hydrochloride can block molecule synthetic ligands and natural endogenous RNA ligands. Enpatoran hydrochloride exhibits excellent pharmacokinetic properties in vivo. Enpatoran hydrochloride can be used for both innate and adaptive autoimmunity blocking research. | ||||||||||||||||||||
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Keywords
