2102672-22-8
2102672-22-8
Chemical Structure
DK419
- CAS No.: 2102672-22-8
- Formula:C16H8ClF6N3O
- Molecular Weight:407.70
IUPAC Name: 5-chloro-2-(trifluoromethyl)-N-(4-(trifluoromethyl)phenyl)-1H-benzo[d]imidazole-7-carboxamide
InChIKey: MWNNIGRGNSXNEA-UHFFFAOYSA-N
SMILES: O=C(C1=C2C(N=C(C(F)(F)F)N2)=CC(Cl)=C1)NC3=CC=C(C(F)(F)F)C=C3
Biological Activity: DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK[1].
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DK419 | 99.86% | DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK. | ||||||||||||||||||||
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