2121989-91-9
2121989-91-9
Chemical Structure
GSK2850163
Synonym(s): GSK163
- CAS No.: 2121989-91-9
- Formula:C24H29Cl2N3O
- Molecular Weight:446.41
IUPAC Name: (R)-2-(3,4-dichlorobenzyl)-N-(4-methylbenzyl)-2,7-diazaspiro[4.5]decane-7-carboxamide
InChIKey: YFDASBFQKMHSSJ-XMMPIXPASA-N
SMILES: O=C(N(CCC1)C[C@]21CCN(CC3=CC=C(Cl)C(Cl)=C3)C2)NCC4=CC=C(C)C=C4
Biological Activity: GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively.
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GSK2850163 | 98.52% | GSK2850163 is a novel inhibitor of inositol-requiring enzyme-1 alpha (IRE1α) which can inhibit IRE1α kinase activity and RNase activity with IC50s of 20 and 200 nM, respectively. | ||||||||||||||||||||
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Keywords
