21253-58-7
21253-58-7
Chemical Structure
4′-DTMP
- CAS No.: 21253-58-7
- Formula:C13H16N4O3
- Molecular Weight:276.30
IUPAC Name: 2-(((6-hydroxy-2-propylheptyl)oxy)carbonyl)benzoic acid
InChIKey: HPOCGNHBIFZCAN-UHFFFAOYSA-N
SMILES: OC1=C(OC)C=C(CC2=CN=C(N)N=C2N)C=C1OC
Biological Activity: 4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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4′-DTMP | 97.0% | 4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.89
HY-B0510RTrimethoprim (Standard) -
Similarity Score 0.89
HY-B0510S3Trimethoprim-13C3 -
Similarity Score 0.88
HY-W7162413',4'-Dihydroxytrimethoprim -
Similarity Score 0.88
HY-B0510BTrimethoprim hydrochloride -
Similarity Score 0.88
HY-177337N-Didesmethyladitoprim -
Similarity Score 0.87
HY-121341Brodimoprim -
Similarity Score 0.86
HY-B1902RDiaveridine (Standard) -
Similarity Score 0.84
HY-B0510S2Trimethoprim-d3 -
Similarity Score 0.84
HY-122289Metioprim -
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